The aetiology of osteoarthritis.
نویسنده
چکیده
Osteoarthritis, which is almost universal in people over 55,' causes symptoms in only some.2 The disease is defined on radiological grounds by loss of joint space, sub-chondral sclerosis, cyst formation and the presence of osteophytes and yet these changes do not relate well to the presence of symptoms,3'4 inflammation in the joint or isotope uptake.5 Indeed, this lack of association between symptoms and X-ray changes has thrown some doubt over the whole concept ofosteoarthritis as a major health problem.6 Furthermore, there is no agreement over its name osteoarthrosis, osteoarthritis and degenerative joint disease are all terms in current use, yet none of them is a completely accurate description and, in the words of Bick when writing on the subject of the rheumatic disorders in 1948, 'The relative advantages of one terminology as against another is insignificant as compared to the advantages of mutual agreement on any one.'8 Is osteoarthritis a disease at all? One author has suggested it is akin to cardiac failure,9 i.e. a response to a variety of insults to the bone and cartilage of the joint. Nevertheless it is still regarded as the major cause ofrheumatic complaints in the population and a considerable amount of morbidity, loss of work and health care arises from it.'0"' Set against this background of confusion and the heterogeneity of the disease, the aetiology remains obscure.
منابع مشابه
Pathways to understanding the genomic aetiology of osteoarthritis
Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding of the biological underpinning of disease development and progression.
متن کاملObesity and osteoarthritis
O steoarthritis is usually considered to be a joint disorder the central pathological feature of which is cartilage destruction. However, this concept has evolved, and today osteoarthritis is generally regarded as a disease that may affect the whole joint (bone, muscles, ligaments and synovium). Although the aetiology of osteoarthritis is not established, the main risk factors are well known an...
متن کاملEvaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data
OBJECTIVES Obesity as measured by body mass index (BMI) is one of the major risk factors for osteoarthritis. In addition, genetic overlap has been reported between osteoarthritis and normal adult height variation. We investigated whether this relationship is due to a shared genetic aetiology on a genome-wide scale. METHODS We compared genetic association summary statistics (effect size, p val...
متن کاملStudy on Frequency, Aetiology and Some Enzymatic Activities of Subclinical Ovine Mastitis in Urmia
متن کامل
The relationship between Osteoarthritis and Osteoporosis in the Relationship between Osteoarthritis and Osteoporosis in A Population of Patients Attending Sari Hospitals
Background and purpose: Osteoarthritis and osteoporosis are the most important causes of skeletal disorders and there are controversies over the relationship between these diseases and other factors. The aim of the present study was to investigate the relationship between osteoarthritis and osteoporosis and also the association between these two diseases and patients’ demographic and lifestyle...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 63 740 شماره
صفحات -
تاریخ انتشار 1987